Aug 21, 2014 enzalutamide in metastatic prostate cancer before chemotherapy beer t. Docetaxel is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Previous therapy should have included an anthracycline. Docetaxel has exhibited significant antitumor activity against prostate cancer, metastatic breast cancer, gastric cancer, and others. The dose for mitomycin is 40mg reconstituted in 20 ml sterile water.
For use in hormone naive metastatic prostate cancer drugs dosage. This usually develops by the second cycle of treatment of a 3weekly regimen. Adding docetaxel taxotere, t to induction chemotherapy with platinum infusional 5fu. The recommended dose of jevtana is based on calculation of the body surface area bsa, and is 20 mgm. G tubulin dependent biochemical assay for the antineoplastic agent taxol and application of the drug in serum. See full prescribing information for docetaxel injection nonalcohol formula. Can be reconstituted via syringe method or using reconstitution supplies provided with bcg. Information for the user docetaxel ebewe 10 mgml concentrate for solution for infusion docetaxel read all of this leaflet carefully before you start using this medicine. Radium223 in combination with docetaxel in patients with. This drug is currently approved in at least one country for use in patients with breast cancer, non small cell lung cancer, hormone refractory prostrate cancer, and many other conditions note.
Docetaxel injection, usp is a sterile, nonpyrogenic, clear, colorless to pale yellow solution at 10 mgml concentration. However, it is especially important to call your doctor right away if you experience any of the following. Docetaxel is a medicine prescribed for treating various cancers, such as lung, breast, and prostate cancer. Toxic deaths, hepatotoxicity, neutropenia, hypersensitivity reactions, and fluid retention. Docetaxel docefrez, taxotere by aaron sturgeon on prezi. Should take place in a biological safety cabinet class ii, type a or in a closed system drug transfer device. Taxotere docetaxel injection, for intravenous use initial u. Docetaxel injection this product information is intended only for residents of the united states. Physician prescribing information docetaxel, 20 mg1 ml vial, u. Review side effects, drug interactions, dosage, and pregnancy. Docetaxel clinical pharmacology mechanism of action.
See full prescribing information for complete boxed. Patients given a standard dose of docetaxel exhibit wide interpatient variation in clearance cl and toxic effects. All patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer should be referred to a genetic counselor. Docetaxel injection, usp is a sterile, nonpyrogenic, clear, colorless to pale yellow solution at. The taxane chemotherapeutic agent docetaxel has been utilized in the management of breast cancer in the adjuvant, neoadjuvant and metastatic setting. Taxotere docetaxel injection concentrate, intravenous infusion. See full prescribing information for docetaxel injection. The preparation of mitomycin should be done using aseptic technique. Taxotere is indicated for the treatment of patients with locally advanced or.
Further dilute for infusion in 250500 ml of ns or d 5 w in a. Cvs caremark administers the prescription benefit plan for the patient identified. Received at least 40% of drug dose, no protocol violation. Physical and chemical stability of taxotere docetaxel one. Enzalutamide in metastatic prostate cancer before chemotherapy. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide.
Please use one of the following formats to cite this article in your essay, paper or report. It may be used by itself or along with other chemotherapy medication. This patients benefit plan requires prior authorization for certain medications in order for the drug to be covered. Docetaxel dtx or dxl, sold under the brand name taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. Effects one study looked at using docetaxel to treat advanced or metastatic breast cancer cancer that has spread to other parts of the body in people who had been unsuccessfully treated with other types of chemotherapy. Combination therapy with docetaxel injection for hormone. Dec 15, 2010 a onevial formulation of the chemotherapy agent taxotere docetaxel is likely to be commercially available in some countries in 2010. This results in the persistence of aberrant microtubule structures. Docetaxel 100 mgm adverse drug reactions occurring in at least 5% of patients are compared for three populations who received docetaxel administered at 100 mgm. Thus, interpatient variability in cyp3a4 activity may account in part for differences in toxicity and cl. Enzalutamide in metastatic prostate cancer before chemotherapy beer t.
Full text presentation and management of docetaxelrelated. Docetaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. Docetaxel taxotere, docefrez is a medication prescribed primarily for the treatment of breast cancer. Taxotere is indicated for the treatment of patients with locally advanced or metastatic breast cancer. If you have any further questions, ask your doctor or pharmacist.
This paper will provide an overview of the current roles of docetaxel in the treatment of. Docetaxel binds specifically to the betatubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. Toxic deaths, hepatotoxicity, neutropenia, hypersensitivity reactions, and fluid retention see full. This emedtv segment describes this drugs uses in more detail, explains how it works, and provides general dosing guidelines. Store unopened vials at 225c in original package to protect from light. Taxotere, in combination with doxorubicin as first line therapy, should be reserved for patients with potentially life threatening disease such as visceral or lung metastatic disease. It is important to call your doctor if you think you are experiencing any treatment side effects.
Docetaxel anhydrous is the anhydrous form of docetaxel, a semisynthetic sidechain analogue of paclitaxel with antineoplastic property. Docetaxel is a white to almostwhite powder with an empirical formula of c 43 h 53 no 14, and a molecular weight of 807. Docetaxel nonalcohol formula docetaxel injection eagle pharmaceuticals, inc. Multinational, randomized, openlabel phase iii trial t. Docetaxel is a chemotherapeutic agent effective in the treatment of various solid tumors. Cytoxan cyclophosphamide for injection, usp cytoxan tablets. The drug is prepared from a precursor extracted from the needle biomass of yew plants.
Dailymed docetaxel injection, solution, concentrate. The black bar at the bottom of the plot represent the quartiles of docetaxel auc in the population with pk sampling. The standard intermittent dosage of docetaxel is 60100 mgm2 every 3 weeks. Physician prescribing information see related articles. Adding docetaxel to cisplatin and fluorouracil in patients with. Docetaxel undergoes metabolism by cytochrome cyp3a4. Compared to the mitomycinvinblastine combination, docetaxel. It should be noted that docetaxel was the first drug whose population pk were evaluated in a. Docetaxel, a more potent semisynthetic derivative of paclitaxel, derived from extracts of the leaves of the european yew tree taxus baccata, was discovered in the 1980s. Mar 12, 2020 docetaxel is a white to almostwhite powder with an empirical formula of c 43 h 53 no 14, and a molecular weight of 807.
Poulenc rorer, collegeville, pa is an antineoplastic agent belonging to the taxoid family. Taxotere in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable nodepositive breast cancer. Highlights of prescribing information these highlights do not include all the information needed to use docetaxel injection nonalcohol formula effectively. Docetaxel injection, solution for intravenous infusion. Docetaxel is the active ingredient in the drug product sold under the trade name taxotere. Taxotere docetaxel injection concentrate is a clear yellow to brownishyellow. Luxlung 3 trial afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with egfr mutations sequist lv et al. Docetaxel in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable nodepositive breast cancer. Docetaxel is a prescription chemotherapy drug used to treat different kinds of cancer, including cancers of the breast, prostate, stomach, head and neck cancers, and nonsmallcell lung cancer. Dailymed docetaxel docetaxel anhydrous injection, solution. Dosage should be reduced by 20% in people who develop grade 3 or 4 diarrhea following exposure to docetaxel, hepatotoxicity defined by liver enzymes at levels. Dec 31, 2019 docetaxel was administered in combination with cisplatin and 5fluorouracil tcf, at dose levels of 75 mgm 2 in a 1hour intravenous infusion day 1 in 28 patients aged 10 to 21 years median 16 years, 17 patients were older than 16.
Full text presentation and management of docetaxel. Docetaxel injection in combination with cisplatin and fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck scchn. Toxic deaths, hepatotoxicity, neutropenia, hypersensitivity reactions, and fluid retention see full prescribing information for complete boxed warning. Docetaxel is associated with arthralgias and myalgias, usually starting 12 days after infusion and lasting up to 5 days 142 r. Pdf nabpaclitaxel dose and schedule in breast cancer. Docetaxel is a white to almostwhite powder with an empirical formula of c 43h 53no 14 3h 2o, and a molecular weight of 861. Store unopened vials at 2025c in original package to protect from light. Docetaxel is commonly associated with significant and sometimes complete hair loss r, 144 r. Cutaneous fibrosis induced by docetaxel cleveland 2000. It is highly lipophilic and practically insoluble in water. Treatment option for men with hormonerefractory metastatic prostate cancer, only if karnofsky performancestatus score is 60% or more nice approved 2006 2. Through control of two significant potential risk factors for crystallizationintervention into the infusion bag by using a onestep technique and temperature by use of refrigerated storageit was postulated that the risk of precipitation would be.
For cisplatin dosage adjustments, see manufacturers prescribing information. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and nonsmallcell lung cancer. Cytoxan cyclophosphamide for injection, usp cytoxan. If the procedure is followed as described, an initial diluted solution of 10 mg docetaxel ml will result. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer. Pharmacokinetics, dynamics and toxicity of docetaxel. Docetaxel is a semisynthetic taxane indicated for the treatment of advanced breast, prostate, and nonsmall cell lung cancers.
At this dose and schedule, myelosuppression is common and neutropenia is. Docetaxel binds to free tubulin and promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly. Docetaxel was previously available as a twovial formulation which included two vials a concentrated docetaxel vial and a diluent vial, resulting in a reconstituted concentration of 10 mgml. The effect of an individuals cytochrome cyp3a4 activity. Docetaxel is an antineoplastic agent that acts by disrupting the micro tubular network in cells that is essential for mitotic and interphase cellular functions.